Pooja (Aparna Nair) and Meera (Anju Raj) are colleagues in a textile shop in the town. They are from different walks of life and become friends after started working in the shop. Pooja and Meera stay at St Mary's Working Women's Hostel. One day when they reach the hostel after work, they are welcomed with the shocking news of a murder. One of the inmates who is missing found killed. Events get complicated with the arrival of the police officer Solomon, the investigating officer. Both Pooja and Meera are under suspicion in connection with the murder. The investigation that follows and the truths that are unraveled form the rest of the story of 'St Marysile Kolapathakam'.