New York substitute science teacher/stand-up comic Richard Martinez - who isn't even remotely effective at either - finally lands a full-time position in Texas through the Teaching Ambassador Program, but his stint falls short when it's discovered he's gay. With only one friendly local behind him, Richard returns to the school as sassy Bianca Del Rio, an outspoken teacher who'll put the unruly students and hypocritical school staff in their proper places, instantly becoming the best teacher he's ever been and the school has ever seen.