Convinced that his buddy Nardo (Thomas Middleditch) is making the mistake of a lifetime by marrying Tracy (Shannon Woodward), Jason (T.J. Miller) puts a dramatic end to their wedding. When the furious bride decides to take her Baja honeymoon solo, Nardo follows her-where the lovesick groom is carjacked and left stranded, naked and penniless in a remote part of the Mexican desert. Helpless, Nardo sends out an SOS to Jason and their pal Evan (Adam Pally), an up-and-coming ad exec slated for an important business meeting the next morning. During their ridiculous attempt to rescue Nardo, the trio embarks on a series of increasingly outrageous misadventures involving con artists, drug smugglers and even the Federales.