Teenagers with life-threatening cancer want to live like any healthy 15-year-olds. At the hospital they share fun and sorrow and jokingly call themselves "Sickos." Three teenagers appear to have a lot of fun in the children's oncology department on the fourth floor of a large hospital. Nick (14) and Iwan (15) both lost a leg as a result of bone cancer. For their friend Olivier (16) an amputation may be the next phase. The fourth of the bunch, Pepijn (15), is so ill and weak that he often stays in his room. Friendship and a deep desire to live keeps the guys mentally balanced. And of course their interest in sexy girls makes them act like any ordinary teenage guy. The sickos cannot walk, but they do risky stunts in their wheelchairs and organize joyrides in the hospital corridors. When Gina (16) arrives, the boys try to seduce her, but she's not interested until she realizes that her hospital stay might go better if she has friends. Sickos is a humorous drama that deals with adolescence and chemotherapy.