In Baton Rouge, Louisiana, Taylor, her boyfriend David and their friends Brice and his girlfriend Naomi travel together on vacation to spend a couple of days with their friends Sharley and her boyfriend Howard in the house of his family. On the next day, they see a missile exploding near the house and soon they learn that the USA is under a biological terrorist attack. Out of the blue, a hostile dog comes to the real estate and they decide to lock the door and go sleep. On the next morning, the dog is still stalking them and Brice kills it with a baseball bat. David decides to take the dog to the CDC and he discovers that the locals have transformed in sort of zombies. The friends are attacked by these zombies and have to find a means to escape and survive the hordes of zombies. Will they survive?