Just like his father, the late Dr Yamashiro, Takuya finds himself targeted by the evil forces of the unstoppable Iron Cross Army. With the vicious mega-villain, Professor Monster, eager to pick up where he left off after his grave injury, Takuya must now embrace his destiny and put his extraordinary newfound abilities to good use to avenge his father's death. Can the amazing Spider-Man, along with the brave Interpol agent, Jûzô Mamiya, thwart the plans of the dangerous megalomaniac?