After the blood-soaked events of The Hamiltons (2006), the cat is out of the bag, and the dysfunctional family of vampires now goes by the name of Thompson. On the run from the law, the Thompson family is scattered across Europe, and Francis needs to drive all the way to rural England in search of help by others of his kind, in the small hamlet of Ludlow. But, there, the ancient vampire clan of the Stuarts has an agenda of their own: one that puts the very survival of the Hamiltons in jeopardy. Is this the end of the line for the Thompsons?