Biyernes Santo follows Roy Asuncion, a former Senator who brings his daughter Aurora to a rest house in a distant province for the Holy Week. Aurora is still traumatized a year later after her mother died in a gruesome supernatural attack. The senator enlists the help of his distant cousin and a young, talented spiritual healer Grace to protect Aurora from dark forces that seem to haunt his family every Holy Week. As the week progresses, Roy, Aurora and Grace lock themselves inside the rest house which had been prepared to protect them from demonic attacks from past experience. By Good Friday, the evil forces intensify - with Jesus dead - forcing Roy and Grace to overcome their personal differences in order to protect Aurora.