Jack Reade is a mild-mannered academic who finally has a chance to publish his own Great American Novel. But just as he thinks his tome will see print, Pete Willoughby, a smug and influential editor, informs Jack that the book will remain locked in publishing purgatory. After an accident befalls Pete, Jack forges a desperate alliance with Carrie Singer, a disgruntled employee who also happens to be the book's number-one fan. Together, they concoct an insane scheme to cover up Pete's death and greenlight the book. Unfortunately, the publishing process is chock full of required approvals, and before long, other denizens of Dennison Publishing begin to fall prey to "accidents."