16-year-old Amy Newhouse, a girl inclined to become a full-time missionary, must fight the biggest battle of her young, promising life - cancer. Her open heart to the people of her school sparks a passionate rally from the community; however, this passion dwindles as her cancer metastasizes. Her cancer seems to miraculously disappear, but just as it seems the community has prevailed and the battle won, Amy discovers that the deadly disease has returned and is incurable. Amy's prayers for healing continue, but with the seemingly dried-up support of her community, and an apparent "no" from God, she dies from the one battle she cannot win; however, her prayer club lives on and grows, proving to all doubters that God has a "Greater Yes" after all.