When his fiancée Lucy falls victim to a mysterious illness, Arthur Holmwood turns to a former rival in her affections - Dr John Seward - for help. Seward calls in his mentor, Professor Van Helsing, who quickly uncovers the terrifying truth; the "illness" that afflicts Lucy is in fact a vampire's curse, and the only cure is a fresh supply of human blood. The discovery of several bodies - each drained of their blood - forces Van Helsing and Seward into a race against time to destroy the curse once and for all.