The Path of the Anaconda narrates memories and reflections about the jungle, but also the final effort to save the northern Amazon forest from destruction, establishing an ecological corridor that connects the Andes Mountains with the Atlantic Ocean through eight countries. Almost 50 years after shaking hands for the very first time, the writer and explorer Wade Davis, author of the book The River, and anthropologist Martín Von Hildebrand, who has devoted his life to protecting the Amazon, meet again to carry out a trip up the rivers and paths that were traveled earlier by the legendary botanist Richard Evans Schultes.