Italy, 15th century. Rodrigo Borgia is a cunning schemer. For thirty years he has worked himself up in the Roman Catholic Church and now has been elected as pope by the college of cardinals. Borgia hasn't any religious motives though, it's all about power for him. With his papal power he starts a reign of terror, eliminating rivals. A new age will start for the Borgia family, he thinks and his four children are the most important pawns. His beautiful daughter Lucrezia and passive son Jofré are married off to tighten bonds with rival families. The same goes for Juan, who is also made captain of the Vatican army. Rodrigo's firstborn Cesare is now cardinal. He doesn't like it all. As the born fighter of the family, he sees himself most fit in the position of Juan. Cesare gets increasingly dissatisfied as cardinal and is more and more agitated by his family. Then Juan suddenly dies after an assault.