Knuckle game is a movie that chronicles the lives of two men, Terry and Preme. It shows how these two people, both from different parts of town became well known as the two best fighters in their respective hoods. It depicts how lies, deceit and trickery lead them into this under ground fighting tournament that takes place in the inner city of New York. As if it were already written, the hands of fate cause these two fighters, the best of the best, to end up crossing paths, and clashing in the tournament. What these two fighters fail to realize is that they are involved in a much bigger and dangerous game than anticipated.