Minkey, a super-spy primate, and his partner Mike were the two best spies in the business. For years, they made every mission possible - But when Mike retired to raise his baby girl, Amelia, he never predicted that life would come full circle. Ten years later, Amelia -- who has invented a revolutionary chemical drill -- is kidnapped and whisked off to Japan by Dr. Farley, who is planning a highly dangerous experiment that could cause a massive earthquake and destroy the entire world. Mike and Minkey partner up one last time for their most important mission ever: saving Amelia -- and the world -- from the clutches of the evil Dr. Farley.