Nishkarsha unfolds the story of a bank robbery organized by terrorists in broad daylight at the Manipal Center in Bangalore city. The bank employees and customers are trapped with nowhere to run. Subhash Chandra, the Commissioner of Police, tries various ways to get into the bank without much luck. Devraj, the kingpin behind the robbery, threatens to start killing the hostages one by one if his demands are not met. The Commissioner summons a special commando force led by Ajay Kumar to aid in the rescue operation.