Attempting to save their group's singing career, Reggie Mendoza (Regine Velasquez), a self-confessed grandma's girl, and Mikki Tolentino (Mikee Cojuangco), a misandrist tomboy and a toast of her family, discover Donnette Legaspi (Donna Cruz), a vainglorious spoiled brat coming from a rich family, while singing in a restroom, to be part of their musical trio, DoReMi. Despite their drastic differences in both their personalities, lifestyle and principles, their shared love for music allowed them to consider pursuing a music career in Japan only to find out at the immigration office of a local airport that a fly-by-night placement or recruitment agency had falsified their documents and faked their passports. Due to this mishap and fear of humiliation and concern of their families, the girls travel to a laid back province, putting themselves in a self-imposed exile after the embarrassment they faced after chasing their dreams. While still considering the idea of becoming successful in show business, the girls help convert a small local restaurant into a mini bar where they can perform to sustain their daily needs and expenses. Their successful stint as vocal performers consistently draw huge crowds, and their popularity in the small town is so immense it reached some people in far places and attracted two record executives to sign them for a recording contract. At the very moment of the group's contract signing, both Donnette and Mikki back out from signing the record deal, leaving a disheartened Reggie to continue as a solo act. As Reggie pursued a career as a successful solo singer, Donnette channeled her efforts to help orphans and other abused children in social welfare, and Mikki, started her own family, and food business with Toto (Gary Estrada), whom she met and fell in love with in the province. In a charitable gala where all three of them unknowingly participate in, the girls are brought together once more as they perform the song they co-wrote together.