In the countryside of the United States of America, Irma Applewood and her husband Roy Applewood have been happily married for twenty-five years and they are model citizens in their community. Roy brings Irma to meet Reverend Dale Muncie, who is their pastor and friend, to tell that he is a woman trapped in a man's body and he will have a sex-change operation. Now Roy has to face the deception of his wife and the intolerance of his colleagues, members of his church and his son Wayne. But Irma loves him and after the impact of the news, she understands and supports him with their teenage daughter Patty Ann (Hayden Panettiere) and Roy's boss Frank ('Clancy Brown') that is their friend.