Aimless 20-something Joey Vitello still lives at home with his colorful Italian-American family when he is reunited with childhood schoolmate Mary O'Callahan. Once mocked as 'Scary Mary,' this ugly duckling has blossomed into an irresistible beauty who has returned to the old neighborhood after an intense bout with cancer. When Joey learns that her cure was the result of a miracle, friendship turns to romance as she educates him on the road to the Almighty. Joey challenges his family's faith with his newfound revelations, and chaos ensues as they all search for their own miracles.