Richard "Richie" Twat and Edward "Eddie" Elizabeth Ndingombaba are two losers who run Guest House Paradiso, the worst hotel in the UK. Guest House Paradiso is next-door to a nuclear power plant, The chef is a illegal immigrant and the waiter is a mental patient who has escaped from a mental hospital. Once the guests check-in, they are dying to check-out. Richie and Eddie's luck is about to change when Gina Carbonara, a Italian movie star checks in and is hiding away from her horrible fiancé Gino Bolognese and the Nice family checks in and Richie discovers Mr. and Mrs. Nice has a rubber bra and underpants. But all hell breaks loose when Richie and Eddie serves radioactive fish to the guests for supper and Gino has tracked Gina down and the guests become very sick.