Kansas City waitress, Betty (Renée Zellweger), with dreams of becoming a nurse, becomes delusional after seeing her no-good car salesman husband murdered. Becoming delusional from shock, she becomes convinced that she is the former fiancée of her soap opera idol. What she also believes is that the soap opera is real and goes to Los Angeles, California to find the hospital where he works as a cardiologist. Meanwhile, her husband's murderers are searching for the drugs stolen by her husband and, as luck would have it, they are stored in the trunk of the car in which she drove off. Charlie (Morgan Freeman), an aging hitman planning his retirement after this job, also becomes delusional about the woman he is tracking.