On the distant mining planet Sirius 6B ravaged by a decade of war in the year 2078, scientists have created the perfect weapon. The blade-wielding, self-replicating race of killing devices known as Screamers is designed for one purpose - to hunt down and destroy all enemy life forms. This so dubbed man's greatest weapon has continued to evolve without human guidance, and devised a new mission: to obliterate all life. Colonel Hendricksson (Peter Weller) commands a handful of Alliance soldiers still alive on Sirius. Betrayed by his own political leaders and disgusted by the atrocities of a never-ending war, Hendricksson decides to negotiate a separate peace with the New Economic Bloc's decimated forces. But to do so, he will have to cross a treacherous wasteland where the deadliest threat comes from the very weapons he helped to create.