Three years after the events in Beverly Hills Cop (1984), the street-wise Detroit detective, Axel Foley, invades the posh city once more, after the assassination attempt on Captain Andrew Bogomil. Against the backdrop of a seemingly endless string of violent and well-orchestrated smash-and-grab robberies known as the "Alphabet Crimes", Detectives Billy Rosewood and John Taggart struggle to solve the case; nevertheless, in vain. Now, a lethally beautiful hitwoman linked to an international arms trafficking ring is the mysterious and elusive prime suspect. Can the brazen and sassy Axel and his partners solve this thorny case, too?