Charming country bumpkin Duane Bradley takes a motel room in New York with a basket and a backpack. In a flashback sequence we learn the basket contains his surgically removed Siamese twin - who is not only so physically deformed the doctors hesitated to consider him a human, but is also the vindictive driver behind their trip, with the purpose of killing off all those he blames. But in one of those doctors' offices, Duane gets his first-ever date, with the receptionist, and wants to start a positive life. When the freak twin escapes, the scene is set for a grim finale.