Burdened with insufferable guilt, renowned Los Angeles ophthalmologist Dr Leonard Chaney becomes obsessed with restoring the eyesight of his only daughter Nancy after surviving a nearly fatal car crash. But with time running out, Dr Chaney has no other choice but to resort to a radical, groundbreaking approach to see results. Now, all that Chaney needs is a willing and compatible donor. However, second chances are hard to come by, and Dr Leonard's dark basement is a painful reminder of his unethical, brutal human experimentation. What horrible secrets lie behind the closed doors of the Mansion of the Doomed?