Carrie, Mitzie, and Chicago get in trouble a lot in the women's prison, but are offered early parolement if they agree to become subjects of a study on human aggression and antisocial behavior at a Kansas City college. Dr. Blalock, the professor in charge of the study, is accepting money under the table from a shady government contact to use an experimental drug on the women. The drug induces the same hostile behavior the doctor is supposedly trying to cure, and after a while the women have a hard time conducting themselves in a civil manner. Carrie begins figuring out the scam and must rely on Blalock's son to help her.