In 16th-century Rome, Rampín, a sympathetic and shameless rogue, exploits his deceptive arts. He lives with his aunt, Napolitana, a gossiper dedicated to the same trades as his nephew. With the arrival of a beautiful Andalusian, Lozana, fortune enters the house by making her the most beautiful courtesan of Rome. Lozana and Rampín reach an agreement: he will be at her service, taking many lovers at home, and she will give him the best, what others will never have. But one day, don Sancho, a handsome Spaniard, falls in love with her.