Doctor Frankenstein runs a few tests in his lab on a dead body. After a few moments the dead body becomes reanimated and screams out in pain. Frankenstein and his assistant Morpho (played by Franco) are murdered by Melisa, a bird/woman creation of the evil sorcerer Cagliostro. He wants to use the monster to create a new race of super humans that are obedient to him. Dr. Vera Frankenstein, also working on reanimation, is crushed to learn of her father's demise before he can share the secrets of his technique. She briefly reanimates him to learn that Cagliostro is at fault and has his monster in Castle Varga. She heads that way, but is caught and trapped by Cagliostro. Under his direction and with her aid, he will select parts from the most desirable of women to create a partner for the male monster. Vera will then bring it to life. Dr. Seward, a local physician who is attracted to Vera, is out to save her. He does not know that she is under a spell until he and an inspector witness the goings on at the castle.