In Harlem, two Italian mobsters meet three black gangsters that work for the kingpin Doc Johnson to collect dirty money from their associates in an apartment building. Out of the blue, the small-time thieves Jim Harris and Joe Logart knock on the door disguised as police officers to steal US$ 300,000.00 from the Mafia. However, they startle when the suitcase with the money falls on the floor and Jim kills the five men with a machine gun. They flee to the runaway car driven by Henry J. Jackson and they kill two policemen. The idealist NYPD Lt. Pope and the violent Capt. Mattelli investigate the case while the Italian Mafia and the black gangsters hunt the killers down. Will Jim Harris and his accomplices be found?