Desiring to start their family, young Catholic homemaker Rosemary Woodhouse and her struggling-actor husband Guy move into The Bramford: New York City's iconic building that brims with unpleasant stories of obscure dwellers and ghastly occurrences. The young couple is soon befriended by their eccentric next-door neighbors, Roman and Minnie and Castevet; shortly afterward, Rosemary gets pregnant. However, little by little--as the inexperienced mother becomes systematically cut off from her circle of friends--alarming hints of a sinister, well-planned conspiracy start to emerge, enfolding timid Rosemary in a shroud of suspicion and mental agony. Why is everyone so conveniently eager to help? And why is Guy allowing it?