In 1943, the British Navy is not able to rescue 2,000 soldiers trapped in the Island of Kheros since two powerful German cannons on the top of the Navarone Island are sinking the Allied vessels. After a failed aerial attack, the Allied command decide to send a six-man team disguised as fishermen to Navarone to blow-up the guns. The squad is commanded by Maj. Roy Franklin and composed by Capt. Keith Mallory, who is an experienced mountain climber, and his former partner Col. Andrea Stavros; the explosive expert Cpl. John Anthony Miller; the engineer CPO 'Butcher' Brown; and the Greek assassin Spyros Pappadimos, who was born in Navarone. They sail during the night and after an encounter with a German patrol boat and a storm in the sea, they arrive to Navarone and Capt. Mallory needs to climb a cliff face during a heavy rainy night to proceed their mission. Will they succeed?