When Sunshine Valley settlers face disaster because of a food shortage and medicine shortage, Gene Autry and Dan Coleman, father of Gene's friend Jennifer, buy supplies in Trail's End, but additional supplies promised by the operators of the town's only store, Lola Riker and her partner Ross McLain are not forthcoming. With the aid of the law and his friend Smiley, Gene gets a shipment through to Sunshine Valley, battling off a hi-jacking attempt but too late to prevent a little girl, Judy, from dying because of a lack of medicine. Gene heads for a showdown battle with McLain.