Belle Andrews' (Constance Bennett) gambling hall burns down in the Chicago fire of 1871 and, now penniless, she accepts Jim Farrel's (Warren William) invitation to accompany him to Powder River, Montana, to open a gambling casino. Farrel has plans to get control of all the land in Powder River by hiring henchmen to file claims on the land, a proceeding overlooked by the settlers. On the stagecoach to Powder River, they meet Wild Bill Hickok (Bruce Cabot). Once there, Farrel has his claim jumpers go to work, and even has Ned Nolan (Russell Simpson) convicted of a framed-up murder charge, and fixes the jury just to be safe. Hickok then begins to organize the settlers to fight back against Farrel.