In 1876, a band of buffalo hunters assembles at Sprague's Trading Post and is joined by Tom Doan, fresh from a Kansas farm. At the post, Tom meets, and falls in love with, Milly Fayre, the stepdaughter of Randall Jett, the leader of a gang of notorious outlaws who make a brutal living robbing buffalo hunters. Milly and Tom are separated, and there is an Indian uprising sparked by the irresponsible slaughtering of the buffalo herds by white adventurers. Jett is killed by his own men, and Milly escapes, attempting to make her way back to civilization. She is chased by a party of hostile Indians and falls in front of a herd of stampeding buffalo. Tom rescues her. The buffalo hunters subdue the Indians, and Tom and Milly head back to civilization.