Inspired by a statue of the infant Christ in the hands of the Madonna, Bernice who lives in a convent in Naples, Italy conceives of a deep passion for babies. Learning that there are infants dying of hunger and neglect in America, Bernice determines to come to their aid. Dressed as a boy, she arrives in New York where destitute, Bernice meets artist Robert Bruce who hires her to pose for a painting of the Madonna. The two fall in love until one day, during Robert's absence, his wife appears and drives Bernice into the streets. Bernice's trials finally end when Mrs. Bruce dies in an automobile accident, freeing Robert to marry his model.