Elsie Drummond, the "Vixen," a spoiled nymphomaniac, takes pleasure in wreaking havoc on her sweet sister Helen. When Helen becomes enamored of Martin Stevens, a Wall Street businessman, Elsie turns on her considerable charms and woos him away. After Charlie Drummond, Elsie's shiftless brother, steals from Stevens and causes a scandal, Stevens is ruined financially and Elsie promptly leaves him. Through deliberate manipulation, Elsie then steals Knowles Murray, a young statesman, from Helen and succeeds in marrying him. Elsie and Murray move to Paris, forcing Helen to care for their alcoholic father. Six years later, Murray is called to Washington, D.C. and Elsie, now the mother of two children, renews her acquaintance with Martin Stevens, who has regained his wealth and position. As Murray is about to catch Elsie in Stevens' arms, Helen, to protect the children, supplies Elsie with an escape and an alibi. While Elsie continues in her deceptive ways, Stevens, finally wise to the Vixen, marries Helen.