McTeague begins life in the mines. He later becomes an unlicensed practicing dentist. He is a man of violent physical passions, but until he meets little Trina, who visits his dental office, his love instincts have never been aroused. McTeague induces Trina to marry him through the sheer force of his domineering personality. The couple are not happy. Trina develops miserly instincts and when she wins a $5,000 lottery prize, she hoards the money and grows more and more avaricious. McTeague quarrels with Marcus, his former rival for Trina's affections, and the ill feeling between the two men leads to a fierce combat in which McTeague proves the victor. In revenge Marcus has McTeague prevented from practicing dentistry because he has no diploma. McTeague leans on Trina for support but she turns him away. Trina has a severe illness and while recuperating develops a mania for fondling her hoarded gold pieces. McTeague returns to find Trina showering handfuls of gold upon her bed. After a terrific scene he strangles her and steals the money. Marcus, determined to avenge Trina's death, trails the fugitive McTeague into the heart of Death Valley, where the two men come at last face to face in a final battle to the death under the blistering desert sun.